Fluorescence resonance energy transfer (FRET)-based ThT free sensing of beta-amyloid fibrillation by carbon dot-Ag composites

• Main Authors: Nair, Radhika Vadakkini, Padmanabhan, Parasuraman, Gulyás, Balázs, Murukeshan, Vadakke Matham
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Physics::Optics and light; Alzheimer’s Disease; Plasmonics
• Online Access: https://hdl.handle.net/10356/148602
• Institution: Nanyang Technological University

Amyloid-beta proteins that form cytotoxic aggregates called amyloid-β derived diffusible ligands are responsible for various neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel methods for the early detection of such aggregates and inhibition of further fibrillation are highly...