Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration

• Main Authors: James, Rachel E., Schalks, Renee, Browne, Eleanor, Eleftheriadou, Ioanna, Munoz, Carmen Picon, Mazarakis, Nicholas D., Reynolds, Richard
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Multiple Sclerosis; Neurodegeneration
• Online Access: https://hdl.handle.net/10356/148650
• Institution: Nanyang Technological University

Analysis of isolated meninges and cerebrospinal fluid (CSF) of post-mortem MS cases has shown increased gene and protein expression for the pro-inflammatory cytokines: tumour necrosis factor (TNF) and interferon-γ (IFNγ). Here we tested the hypothesis that persistent production of these cytokines in...