Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome

• Main Authors: Botté, Alexandra, Lainé, Jeanne, Xicota, Laura, Heiligenstein, Xavier, Fontaine, Gaëlle, Kasri, Amal, Rivals, Isabelle, Goh, Pollyanna, Faklaris, Orestis, Cossec, Jack-Christophe, Morel, Etienne, Rebillat, Anne-Sophie, Nizetic, Dean, Raposo, Graça, Potier, Marie-Claude
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Down Syndrome; Alzheimer’s Disease
• Online Access: https://hdl.handle.net/10356/148651
• Institution: Nanyang Technological University

Enlarged early endosomes have been visualized in Alzheimer's disease (AD) and Down syndrome (DS) using conventional confocal microscopy at a resolution corresponding to endosomal size (hundreds of nm). In order to overtake the diffraction limit, we used super-resolution structured illumination...