Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis

• Main Authors: Ho, Wan Yun, Navakkode, Sheeja, Liu, Fujia, Soong, Tuck Wah, Ling, Shuo-Chien
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Medicine; Amyotrophic Lateral Sclerosis; Frontotemporal Dementia
• 在線閱讀: https://hdl.handle.net/10356/148652
• 機構: Nanyang Technological University

Hexanucleotide repeat expansion of C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Synergies between loss of C9ORF72 functions and gain of toxicities from the repeat expansions contribute to C9ORF72-mediated pathogenesis. However, how loss of C9...