C9orf72 expansions are the most common cause of genetic frontotemporal dementia in a Southeast Asian cohort

• Main Authors: Tan, Yi Jayne, Yong, Alisa C. W., Foo, Jia Nee, Lian, Michelle M., Lim, Weng Khong, Dominguez, Jacqueline, Fong, Zhi Hui, Narasimhalu, Kaavya, Chiew, Hui Jin, Ng, Kok Pin, Ting, Simon K. S., Kandiah, Nagaendran, Ng, Adeline S. L.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Alzheimer Disease; Amyotrophic Lateral Sclerosis
• Online Access: https://hdl.handle.net/10356/169821
• Institution: Nanyang Technological University

Objective: Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative disorders, including behavioural variant FTD (bvFTD), semantic variant primary progressive aphasia (svPPA) and non-fluent variant PPA (nfvPPA). While a strong genetic component is implicated in FTD, genetic FTD in...