Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility

• Main Authors: Xing, Qiao Rui, Farran, Chadi A. El, Zeng, Yingying, Yi, Yao, Warrier, Tushar, Gautam, Pradeep, Collins, James J., Xu, Jian, Dröge, Peter, Koh, Cheng-Gee, Li, Hu, Zhang, Li-Feng, Loh, Yuin-Han
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Cis Regulatory Element; Transcription Factor
• Online Access: https://hdl.handle.net/10356/148682
• Institution: Nanyang Technological University

Joint profiling of transcriptome and chromatin accessibility within single cells allows for the deconstruction of the complex relationship between transcriptional states and upstream regulatory programs determining different cell fates. Here, we developed an automated method with high sensitivity, a...