Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells

• Main Authors: Yi, Yao, Zeng, Yingying, Sam, Tsz Wing, Hamashima, Kiyofumi, Tan, Rachel Jun Rou, Warrier, Tushar, Phua, Jun Xiang, Taneja, Reshma, Liou, Yih-Cherng, Li, Hu, Xu, Jian, Loh, Yuin-Han
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/169689
• Institution: Nanyang Technological University

A rare sub-population of mouse embryonic stem cells (mESCs), the 2-cell-like cell, is defined by the expression of MERVL and 2-cell-stage-specific transcript (2C transcript). Here, we report that the ribosomal proteins (RPs) RPL14, RPL18, and RPL23 maintain the identity of mESCs and regulate the exp...