RNA interference in glial cells for nerve injury treatment

RNA interference in glial cells for nerve injury treatment

Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat n...

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Bibliographic Details
Main Authors: Lin, Junquan, Jo, Seung Bin, Kim, Tae-Hyun, Kim, Hae-Won, Chew, Sing Yian
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2021
Subjects:
Engineering::Bioengineering
RNA Interference
Central Nervous System
Online Access:https://hdl.handle.net/10356/148964
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Institution: Nanyang Technological University
Language: English
Description
Summary:Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.

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