RNA interference in glial cells for nerve injury treatment

Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat n...

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Main Authors:	Lin, Junquan, Jo, Seung Bin, Kim, Tae-Hyun, Kim, Hae-Won, Chew, Sing Yian
Other Authors:	School of Chemical and Biomedical Engineering
Format:	Article
Language:	English
Published:	2021
Subjects:	Engineering::Bioengineering RNA Interference Central Nervous System
Online Access:	https://hdl.handle.net/10356/148964
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-148964
record_format	dspace
spelling	sg-ntu-dr.10356-1489642023-03-05T16:44:24Z RNA interference in glial cells for nerve injury treatment Lin, Junquan Jo, Seung Bin Kim, Tae-Hyun Kim, Hae-Won Chew, Sing Yian School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine (LKCMedicine) Engineering::Bioengineering RNA Interference Central Nervous System Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed. Ministry of Education (MOE) Ministry of Health (MOH) National Medical Research Council (NMRC) National Research Foundation (NRF) Published version The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: SY Chew and J Lin would like to acknowledge partial funding support from the Singapore National Research Foundation under its National Medical Research Council Cooperative Basic Research Grant (NMRC-CBRG, NMRC/CBRG/0096/2015) and administered by the Singapore Ministry of Health’s National Medical Research Council; Ministry of Education Tier 1 grant (RG38/19). This research was supported in part by the National Research Foundation (NRF), Republic of Korea (2015K1A1A2032163, 2018K1A4A3A01064257, 2018R1A2B3003446). 2021-06-03T07:53:04Z 2021-06-03T07:53:04Z 2020 Journal Article Lin, J., Jo, S. B., Kim, T., Kim, H. & Chew, S. Y. (2020). RNA interference in glial cells for nerve injury treatment. Journal of Tissue Engineering, 11, 1-17. https://dx.doi.org/10.1177/2041731420939224 2041-7314 0000-0001-6400-6100 0000-0002-6084-5967 https://hdl.handle.net/10356/148964 10.1177/2041731420939224 32670539 2-s2.0-85087475773 11 1 17 en NMRC-CBRG NMRC/CBRG/0096/2015 RG38/19 Journal of Tissue Engineering © 2020 The Author(s). This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Engineering::Bioengineering RNA Interference Central Nervous System
spellingShingle	Engineering::Bioengineering RNA Interference Central Nervous System Lin, Junquan Jo, Seung Bin Kim, Tae-Hyun Kim, Hae-Won Chew, Sing Yian RNA interference in glial cells for nerve injury treatment
description	Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.
author2	School of Chemical and Biomedical Engineering
author_facet	School of Chemical and Biomedical Engineering Lin, Junquan Jo, Seung Bin Kim, Tae-Hyun Kim, Hae-Won Chew, Sing Yian
format	Article
author	Lin, Junquan Jo, Seung Bin Kim, Tae-Hyun Kim, Hae-Won Chew, Sing Yian
author_sort	Lin, Junquan
title	RNA interference in glial cells for nerve injury treatment
title_short	RNA interference in glial cells for nerve injury treatment
title_full	RNA interference in glial cells for nerve injury treatment
title_fullStr	RNA interference in glial cells for nerve injury treatment
title_full_unstemmed	RNA interference in glial cells for nerve injury treatment
title_sort	rna interference in glial cells for nerve injury treatment
publishDate	2021
url	https://hdl.handle.net/10356/148964
_version_	1759856683797970944

RNA interference in glial cells for nerve injury treatment

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