2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease

• المؤلفون الرئيسيون: Patil, Nitin A., Quek, Jun-Ping, Schroeder, Barbara, Morewood, Richard, Rademann, Jörg, Luo, Dahai, Nitsche, Christoph
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Medicine; Macrocyclization; Peptides
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/149908
• المؤسسة: Nanyang Technological University

The rapid generation and modification of macrocyclic peptides in medicinal chemistry is an ever-growing area that can present various synthetic challenges. The reaction between N-terminal cysteine and 2-cyanoisonicotinamide is a new biocompatible click reaction that allows rapid access to macrocycli...