2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease

2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease

The rapid generation and modification of macrocyclic peptides in medicinal chemistry is an ever-growing area that can present various synthetic challenges. The reaction between N-terminal cysteine and 2-cyanoisonicotinamide is a new biocompatible click reaction that allows rapid access to macrocycli...

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Bibliographic Details
Main Authors: Patil, Nitin A., Quek, Jun-Ping, Schroeder, Barbara, Morewood, Richard, Rademann, Jörg, Luo, Dahai, Nitsche, Christoph
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2021
Subjects:
Science::Medicine
Macrocyclization
Peptides
Online Access:https://hdl.handle.net/10356/149908
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/149908

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