A short chemically modified dsRNA-Binding PNA (dbPNA) inhibits influenza viral replication by targeting viral RNA panhandle structure

• المؤلفون الرئيسيون: Kesy, Julita, Patil, Kiran M., Kumar, Subaschandrabose Rajesh, Shu, Zhiyu, Yong, Hui Yee, Zimmermann, Louis, Ong, Alan Ann Lerk, Toh, Desiree-Faye Kaixin, Krishna, Manchugondanahalli S., Yang, Lixia, Decout, Jean-Luc, Luo, Dahai, Prabakaran, Mookkan, Chen, Gang, Kierzek, Elzbieta
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Chemistry; dbPNA; Influenza
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/150015

RNAs play critical roles in diverse catalytic and regulatory biological processes and are emerging as important disease biomarkers and therapeutic targets. Thus, developing chemical compounds for targeting any desired RNA structures has great potential in biomedical applications. The viral and cellu...