Naturally-occurring polymorphisms in QcrB are responsible for resistance to Telacebec in Mycobacterium abscessus

• Main Authors: Sorayah, Ria, Manimekalai, Malathy Sony Subramanian, Shin, Sung Jae, Koh, Won-Jung, Grüber, Gerhard, Pethe, Kevin
• Other Authors: Interdisciplinary Graduate School (IGS)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Telacebec; Cytochrome bc1:aa3
• Online Access: https://hdl.handle.net/10356/150611
• Institution: Nanyang Technological University

Mycobacterium abscessus (M. abscessus) is a rapidly growing nontuberculous mycobacteria that is quickly emerging as a global health concern. M. abscessus pulmonary infections are frequently intractable due to the high intrinsic resistance to most antibiotics. Therefore, there is an urgent need to di...