Surface protein engineering increases the circulation time of a cell membrane-based nanotherapeutic

• المؤلفون الرئيسيون: Krishnamurthy, Sangeetha, Muthukumaran, Padmalosini, Jayakumar, Muthu Kumara Gnanasammandhan, Lisse, Domenik, Masurkar, Nihar D., Xu, Chenjie, Chan, Juliana M., Drum, Chester L.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Medicine; PASylation; Nanoghosts
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/150808
• المؤسسة: Nanyang Technological University

Mammalian cell membranes are often incompatible with chemical modifications typically used to increase circulation half-life. Using cellular nanoghosts as a model, we show that proline-alanine-serine (PAS) peptide sequences expressed on the membrane surface can extend the circulation time of a cell...