Unconventional split aptamers cleaved at functionally essential sites preserve biorecognition capability

• Main Authors: Wang, Ruoyu, Zhang, Qiansen, Zhang, Yi, Shi, Hanchang, Nguyen, Kim Truc, Zhou, Xiaohong
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::General; Peptides and Proteins; Monomers
• Online Access: https://hdl.handle.net/10356/150833
• Institution: Nanyang Technological University

Split aptamers (SPAs) are a pair of oligonucleotide fragments generated by cleaving a long parent aptamer. SPAs have many compelling advantages over the parent aptamer such as sandwich target binding, optimized concise structure, and low cost. However, only a limited number of SPAs have been develop...