An upconversion nanoparticle enables near infrared-optogenetic manipulation of the Caenorhabditis elegans motor circuit

• Main Authors: Ao, Yanxiao, Zeng, Kanghua, Yu, Bin, Miao, Yu, Hung, Wesley, Yu, Zhongzheng, Xue, Yanhong, Tan, Timothy Thatt Yang, Xu, Tao, Zhen, Mei, Yang, Xiangliang, Zhang, Yan, Gao, Shangbang
• 其他作者: School of Chemical and Biomedical Engineering
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Engineering::Chemical engineering; Lanthanide Upconversion Nanoparticle; Optogenetics
• 在線閱讀: https://hdl.handle.net/10356/151231

Near-infrared (NIR) light penetrates tissue deeply, but its application to motor behavior stimulation has been limited by the lack of known genetic NIR light-responsive sensors. We designed and synthesized a Yb³⁺/Er³⁺/Ca²⁺-based lanthanide-doped upconversion nanoparticle (UCNP) that effectively conv...