An upconversion nanoparticle enables near infrared-optogenetic manipulation of the Caenorhabditis elegans motor circuit

• Main Authors: Ao, Yanxiao, Zeng, Kanghua, Yu, Bin, Miao, Yu, Hung, Wesley, Yu, Zhongzheng, Xue, Yanhong, Tan, Timothy Thatt Yang, Xu, Tao, Zhen, Mei, Yang, Xiangliang, Zhang, Yan, Gao, Shangbang
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Chemical engineering; Lanthanide Upconversion Nanoparticle; Optogenetics
• Online Access: https://hdl.handle.net/10356/151231
• Institution: Nanyang Technological University

Near-infrared (NIR) light penetrates tissue deeply, but its application to motor behavior stimulation has been limited by the lack of known genetic NIR light-responsive sensors. We designed and synthesized a Yb³⁺/Er³⁺/Ca²⁺-based lanthanide-doped upconversion nanoparticle (UCNP) that effectively conv...