Lipid-polymer hybrid nanoparticles enhance the potency of ampicillin against Enterococcus faecalis in a protozoa infection model

• Main Authors: Tan, Chuan Hao, Jiang, Lai, Li, Wenrui, Chan, Siew Herng, Baek, Jong-Suep, Ng, Noele Kai Jing, Sailov, Talgat, Kharel, Sharad, Chong, Kelvin Kian Long, Loo, Joachim Say Chye
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences::Microbiology::Bacteria; Engineering::Materials::Biomaterials; Antibiotics; Nanoparticles
• Online Access: https://hdl.handle.net/10356/151248; https://doi.org/10.21979/N9/OIUE5O
• Institution: Nanyang Technological University

Enterococcus faecalis (E. faecalis) biofilms are implicated in endocarditis, urinary tract infections, and biliary tract infections. Coupled with E. faecalis internalization into host cells, this opportunistic pathogen poses great challenges to conventional antibiotic therapy. The inability of ampic...