Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis

• المؤلفون الرئيسيون: da Silva, Ronni A. G., Wong, Jun Jie, Antypas, Haris, Choo, Pei Yi, Goh, Karlyn, Jolly, Shreya, Liang, Cui, Tay, Leona Kwan Sing, Veleba, Mark, Hu, Guangan, Chen, Jianzhu, Kline, Kimberly A.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Biological sciences; Antibiotics Resistance
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/169848

Antibiotic resistance critically limits treatment options for infection caused by opportunistic pathogens such as enterococci. Here, we investigate the antibiotic and immunological activity of the anticancer agent mitoxantrone (MTX) in vitro and in vivo against vancomycin-resistant Enterococcus faec...