Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis

• Main Authors: da Silva, Ronni A. G., Wong, Jun Jie, Antypas, Haris, Choo, Pei Yi, Goh, Karlyn, Jolly, Shreya, Liang, Cui, Tay, Leona Kwan Sing, Veleba, Mark, Hu, Guangan, Chen, Jianzhu, Kline, Kimberly A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Antibiotics Resistance
• Online Access: https://hdl.handle.net/10356/169848
• Institution: Nanyang Technological University

Antibiotic resistance critically limits treatment options for infection caused by opportunistic pathogens such as enterococci. Here, we investigate the antibiotic and immunological activity of the anticancer agent mitoxantrone (MTX) in vitro and in vivo against vancomycin-resistant Enterococcus faec...