O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy

Tumor therapy is facing great challenges in improving drug efficiency while reducing side effects. Herein, a novel multifunctional nanodrug carrier UC@mSiO2-RB@ZIF-O2-DOX-PEGFA (URODF) that combines oxygen (O2)-enhanced photodynamic therapy (PDT) with pH-responsive chemotherapy is presented. Eight h...

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Main Authors: Xie, Zhongxi, Cai, Xuechao, Sun, Chunqiang, Liang, Shuang, Shao, Shuai, Huang, Shanshan, Cheng, Ziyong, Pang, Maolin, Xing, Bengang, Al-Kheraif, Abdulaziz Abdullah, Lin, Jun
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/151307
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spelling sg-ntu-dr.10356-1513072021-07-06T01:40:35Z O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy Xie, Zhongxi Cai, Xuechao Sun, Chunqiang Liang, Shuang Shao, Shuai Huang, Shanshan Cheng, Ziyong Pang, Maolin Xing, Bengang Al-Kheraif, Abdulaziz Abdullah Lin, Jun School of Physical and Mathematical Sciences Science::Chemistry Cancer Therapy Luminescence Tumor therapy is facing great challenges in improving drug efficiency while reducing side effects. Herein, a novel multifunctional nanodrug carrier UC@mSiO2-RB@ZIF-O2-DOX-PEGFA (URODF) that combines oxygen (O2)-enhanced photodynamic therapy (PDT) with pH-responsive chemotherapy is presented. Eight hundred eight nanometer NIR light-irradiated NaYF4:Yb/Er@NaYbF4:Nd@NaGdF4 nanoparticles (UC) were employed as both upconversion/magnetic resonance imaging matrix and motivator for photosensitizer in PDT with deep penetration depth. Mesoporous silica shell (mSiO2) was used as the carrier for photosensitizer Rose Bengal (RB). Zeolitic imidazolate framework-90 (ZIF-90) was coated outside of mSiO2 as O2 reservoir to quickly release O2 in tumor microenvironment and alleviate tumor hypoxia for enhanced PDT. Doxorubicin (DOX) and NH2-poly(ethylene glycol) modified folic acid (PEGFA) were covalently conjugated on the surface of nanoparticles for synergetic therapy. The drug-loading capacity reaches 5.6 and 6.0% for RB and DOX, respectively. In vitro and in vivo experiments demonstrate great therapeutic effect of URODF. This work presents for the first time a multifunctional nanodrug carrier that combines upconversion nanoparticles with metal–organic framework structure for O2-loaded combination therapy, which might open a promising way of enhancing tumor therapeutic efficacy. This project is financially supported by the National Natural Science Foundation of China (NSFC 51720105015, 51332008, 51828202, 51628201, 51772288, 51572257, and 21728101), Chinese Academy of Sciences (YZDY-SSWJSC018), CAS-Croucher Funding Scheme for Joint Laboratories (CAS18204), and the Science and Technology Development Plan of Jilin Province (20170101187JC and 20170414003GH), Jiangmen Innovative Research Team Program (2017), and Major program of basic research and applied research of Guangdong Province (2017KZDXM083), and the Distinguished Scientist Fellowship Program of King Saud University as well as the Deanship of Scientific Research at King Saud University for funding this work through research group (RG-1939-038). 2021-07-06T01:40:35Z 2021-07-06T01:40:35Z 2018 Journal Article Xie, Z., Cai, X., Sun, C., Liang, S., Shao, S., Huang, S., Cheng, Z., Pang, M., Xing, B., Al-Kheraif, A. A. & Lin, J. (2018). O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy. Chemistry of Materials, 31(2), 483-490. https://dx.doi.org/10.1021/acs.chemmater.8b04321 0897-4756 0000-0001-5125-4615 0000-0002-8391-1234 0000-0001-9572-2134 https://hdl.handle.net/10356/151307 10.1021/acs.chemmater.8b04321 2-s2.0-85060312550 2 31 483 490 en Chemistry of Materials © 2018 American Chemical Society. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Cancer Therapy
Luminescence
spellingShingle Science::Chemistry
Cancer Therapy
Luminescence
Xie, Zhongxi
Cai, Xuechao
Sun, Chunqiang
Liang, Shuang
Shao, Shuai
Huang, Shanshan
Cheng, Ziyong
Pang, Maolin
Xing, Bengang
Al-Kheraif, Abdulaziz Abdullah
Lin, Jun
O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy
description Tumor therapy is facing great challenges in improving drug efficiency while reducing side effects. Herein, a novel multifunctional nanodrug carrier UC@mSiO2-RB@ZIF-O2-DOX-PEGFA (URODF) that combines oxygen (O2)-enhanced photodynamic therapy (PDT) with pH-responsive chemotherapy is presented. Eight hundred eight nanometer NIR light-irradiated NaYF4:Yb/Er@NaYbF4:Nd@NaGdF4 nanoparticles (UC) were employed as both upconversion/magnetic resonance imaging matrix and motivator for photosensitizer in PDT with deep penetration depth. Mesoporous silica shell (mSiO2) was used as the carrier for photosensitizer Rose Bengal (RB). Zeolitic imidazolate framework-90 (ZIF-90) was coated outside of mSiO2 as O2 reservoir to quickly release O2 in tumor microenvironment and alleviate tumor hypoxia for enhanced PDT. Doxorubicin (DOX) and NH2-poly(ethylene glycol) modified folic acid (PEGFA) were covalently conjugated on the surface of nanoparticles for synergetic therapy. The drug-loading capacity reaches 5.6 and 6.0% for RB and DOX, respectively. In vitro and in vivo experiments demonstrate great therapeutic effect of URODF. This work presents for the first time a multifunctional nanodrug carrier that combines upconversion nanoparticles with metal–organic framework structure for O2-loaded combination therapy, which might open a promising way of enhancing tumor therapeutic efficacy.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Xie, Zhongxi
Cai, Xuechao
Sun, Chunqiang
Liang, Shuang
Shao, Shuai
Huang, Shanshan
Cheng, Ziyong
Pang, Maolin
Xing, Bengang
Al-Kheraif, Abdulaziz Abdullah
Lin, Jun
format Article
author Xie, Zhongxi
Cai, Xuechao
Sun, Chunqiang
Liang, Shuang
Shao, Shuai
Huang, Shanshan
Cheng, Ziyong
Pang, Maolin
Xing, Bengang
Al-Kheraif, Abdulaziz Abdullah
Lin, Jun
author_sort Xie, Zhongxi
title O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy
title_short O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy
title_full O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy
title_fullStr O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy
title_full_unstemmed O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy
title_sort o2-loaded ph-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy
publishDate 2021
url https://hdl.handle.net/10356/151307
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