O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy

• Main Authors: Xie, Zhongxi, Cai, Xuechao, Sun, Chunqiang, Liang, Shuang, Shao, Shuai, Huang, Shanshan, Cheng, Ziyong, Pang, Maolin, Xing, Bengang, Al-Kheraif, Abdulaziz Abdullah, Lin, Jun
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Cancer Therapy; Luminescence
• Online Access: https://hdl.handle.net/10356/151307
• Institution: Nanyang Technological University

Tumor therapy is facing great challenges in improving drug efficiency while reducing side effects. Herein, a novel multifunctional nanodrug carrier UC@mSiO2-RB@ZIF-O2-DOX-PEGFA (URODF) that combines oxygen (O2)-enhanced photodynamic therapy (PDT) with pH-responsive chemotherapy is presented. Eight h...