Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

• Main Authors: Subramanian, Karthik, Neill, Daniel R., Malak, Hesham A., Spelmink, Laura, Khandaker, Shadia, Dalla Libera Marchiori, Giorgia, Dearing, Emma, Kirby, Alun, Yang, Marie, Achour, Adnane, Nilvebrant, Johan, Nygren, Per-Åke, Plant, Laura, Kadioglu, Aras, Henriques-Normark, Birgitta
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Bacterial Host Response; Bacterial Pathogenesis
• Online Access: https://hdl.handle.net/10356/151342
• Institution: Nanyang Technological University

Streptococcus pneumoniae (the pneumococcus) is a major cause of mortality and morbidity globally, and the leading cause of death in children under 5 years old. The pneumococcal cytolysin pneumolysin (PLY) is a major virulence determinant known to induce pore-dependent pro-inflammatory responses. The...