PEGylation of silica coated hydroxyapatite nanoparticles for targeted drug delivery

• Main Author: Tang, Andrew BingXiang.
• Other Authors: Loo Say Chye Joachim
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Engineering::Materials
• Online Access: http://hdl.handle.net/10356/15138
• Institution: Nanyang Technological University

Hydroxyapatite (HA, Ca10(PO4)6(OH)2) was synthesised using the double inverse microemulsion (DIME) method. It was then surfaced modified with silica. Silica was then coated on the HA particles using a method based on the Stober process. Poly(ethylene glycol) methyl ether (PEGME, Mw= 5000) was first...