Invalidation of the transcriptional modulator of lipid metabolism PPARβ/δ in T cells prevents age-related alteration of body composition and loss of endurance capacity

• Main Authors: Rousseau, Anne-Sophie, Murdaca, Joseph, Le Menn, Gwenaëlle, Sibille, Brigitte, Wahli, Walter, Le Garf, Sébastien, Chinetti, Giulia, Neels, Jaap G., Mothe-Satney, Isabelle
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Regulatory T Cells; Skeletal Muscle
• Online Access: https://hdl.handle.net/10356/151773
• Institution: Nanyang Technological University

Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4⁺ T cells by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate in secondary lymphoid organs and are involved in impairment of skeletal muscle (S...