Biological consequences of error during ribosome biogenesis

• Main Author: Tan, Xue Wei
• Other Authors: Choe Young Jun
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2021
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/152343
• Institution: Nanyang Technological University

Rpl24, a eukaryotic 60S ribosomal protein, forms inter-subunit bridges. Lack of Rpl24 protein may weaken inter-subunit association, introducing problems during translation such as ribosome stalling. Ribosome stalling produces stalled polypeptides which accumulate to form toxic aggregates if undegrad...