Contribution of metabolic alterations to genome instability and its association with cancer development
Metabolic reprogramming could promote genome instability, causing normal cells to acquire somatic mutations that favours tumourigenesis. To investigate this, ATP citrate lyase (ACLY) was overexpressed in normal epithelial cells, where it induced the formation of micronuclei, nuclear budding and nucl...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2021
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| Online Access: | https://hdl.handle.net/10356/152423 |
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| Institution: | Nanyang Technological University |
| Language: | English |