Exploring the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the pathophysiology of pancreatic diseases
Acute pancreatitis (AP), chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) represent three of the most common disorders affecting the exocrine pancreas. Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a secreted glycoprotein previously implicated in tissue angiogenesis, inflammatio...
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sg-ntu-dr.10356-1525122023-08-13T15:38:20Z Exploring the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the pathophysiology of pancreatic diseases Lim, Seok Ting Luo Dahai Lee Kong Chian School of Medicine (LKCMedicine) Wang Xiaomeng LuoDahai@ntu.edu.sg Science::Biological sciences::Molecular biology Acute pancreatitis (AP), chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) represent three of the most common disorders affecting the exocrine pancreas. Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a secreted glycoprotein previously implicated in tissue angiogenesis, inflammation, fibrosis and cancer progression. Given that these processes also undergird pancreatic disease development, this study therefore hypothesizes a role of LRG1 in AP, CP and PDAC. LRG1 was shown to be significantly upregulated in the pancreas following caerulein-induced development of AP & CP in mice. Lrg1-deficient mice displayed more severe acinar cell damage and inflammatory response during AP and had exacerbated fibrosis and acinar-ductal metaplasia during CP. Additionally, Lrg1-overexpressing orthotopic tumours generated within wild-type mice were larger in volume compared to their control counterparts, in part due to increased tumour cell proliferation and reduced tumour inflammation and desmoplasia. Taken together, the data provides compelling evidence of the role of LRG1 in the pathophysiology of various pancreatic diseases. Doctor of Philosophy 2021-08-30T07:28:28Z 2021-08-30T07:28:28Z 2021 Thesis-Doctor of Philosophy Lim, S. T. (2021). Exploring the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the pathophysiology of pancreatic diseases. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/152512 https://hdl.handle.net/10356/152512 10.32657/10356/152512 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
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Science::Biological sciences::Molecular biology Lim, Seok Ting Exploring the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the pathophysiology of pancreatic diseases |
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Acute pancreatitis (AP), chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) represent three of the most common disorders affecting the exocrine pancreas. Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a secreted glycoprotein previously implicated in tissue angiogenesis, inflammation, fibrosis and cancer progression. Given that these processes also undergird pancreatic disease development, this study therefore hypothesizes a role of LRG1 in AP, CP and PDAC.
LRG1 was shown to be significantly upregulated in the pancreas following caerulein-induced development of AP & CP in mice. Lrg1-deficient mice displayed more severe acinar cell damage and inflammatory response during AP and had exacerbated fibrosis and acinar-ductal metaplasia during CP. Additionally, Lrg1-overexpressing orthotopic tumours generated within wild-type mice were larger in volume compared to their control counterparts, in part due to increased tumour cell proliferation and reduced tumour inflammation and desmoplasia.
Taken together, the data provides compelling evidence of the role of LRG1 in the pathophysiology of various pancreatic diseases. |
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Luo Dahai |
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Luo Dahai Lim, Seok Ting |
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Thesis-Doctor of Philosophy |
author |
Lim, Seok Ting |
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Lim, Seok Ting |
title |
Exploring the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the pathophysiology of pancreatic diseases |
title_short |
Exploring the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the pathophysiology of pancreatic diseases |
title_full |
Exploring the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the pathophysiology of pancreatic diseases |
title_fullStr |
Exploring the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the pathophysiology of pancreatic diseases |
title_full_unstemmed |
Exploring the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the pathophysiology of pancreatic diseases |
title_sort |
exploring the role of leucine-rich alpha-2-glycoprotein 1 (lrg1) in the pathophysiology of pancreatic diseases |
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Nanyang Technological University |
publishDate |
2021 |
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https://hdl.handle.net/10356/152512 |
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1779156641159053312 |