Liposome interaction with macrophages and foam cells for atherosclerosis treatment : effects of size, surface charge and lipid composition

• Main Authors: Tang, Jinkai, Rakshit, Moumita, Chua, Huei Min, Darwitan, Anastasia, Nguyen, Luong T. H., Muktabar, Aristo, Venkatraman, Subbu, Ng, Kee Woei
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Bioengineering; Engineering::Nanotechnology; Science::Biological sciences; Liposome; Atherosclerosis; Macrophage; Foam Cells
• Online Access: https://hdl.handle.net/10356/152845
• Institution: Nanyang Technological University

Liposomes are potential drug carriers for atherosclerosis therapy due to low immunogenicity and ease of surface modifications that allow them to have prolonged circulation half-life and specifically target atherosclerotic sites to increase uptake efficiency. However, the effects of their size, charg...