Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice

Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice

Neutrophils are important for immune surveillance of tumour cells. Neutrophils may also be epigenetically programmed in the tumour microenvironment to promote tumour progression. In addition to the commonly known high-density neutrophils (HDN) based on their separation on density gradient, recent st...

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Main Authors: Lim, Chew Leng, Lin, Valerie Chun Ling
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Neutrophils
Mammary Involution
Online Access:https://hdl.handle.net/10356/152924
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1529242023-02-28T16:59:05Z Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice Lim, Chew Leng Lin, Valerie Chun Ling School of Biological Sciences Science::Biological sciences Neutrophils Mammary Involution Neutrophils are important for immune surveillance of tumour cells. Neutrophils may also be epigenetically programmed in the tumour microenvironment to promote tumour progression. In addition to the commonly known high-density neutrophils (HDN) based on their separation on density gradient, recent studies have reported the presence of high levels of low-density neutrophils (LDN) in tumour-bearing mice and cancer patients. We reported previously that estrogen promotes the growth of estrogen receptor α-negative mammary tumours in mice undergoing mammary involution through stimulating pro-tumoral activities of neutrophils in the mammary tissue. Ministry of Education (MOE) Published version This work was supported by the Ministry of Education of Singapore, Academic Research Fund Tier II, MOE2014-T2-2-125 and Tier I, MOE2017-T1- 002-08. 2021-10-21T04:47:34Z 2021-10-21T04:47:34Z 2021 Journal Article Lim, C. L. & Lin, V. C. L. (2021). Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice. BMC Cancer, 21, 1017-. https://dx.doi.org/10.1186/s12885-021-08751-2 1471-2407 https://hdl.handle.net/10356/152924 10.1186/s12885-021-08751-2 34511060 2-s2.0-85114753042 21 1017 en MOE2014-T2-2-125 MOE2017-T1- 002-08 BMC Cancer © The Author(s). 2021 Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences
Neutrophils
Mammary Involution
spellingShingle Science::Biological sciences
Neutrophils
Mammary Involution
Lim, Chew Leng
Lin, Valerie Chun Ling
Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice
description Neutrophils are important for immune surveillance of tumour cells. Neutrophils may also be epigenetically programmed in the tumour microenvironment to promote tumour progression. In addition to the commonly known high-density neutrophils (HDN) based on their separation on density gradient, recent studies have reported the presence of high levels of low-density neutrophils (LDN) in tumour-bearing mice and cancer patients. We reported previously that estrogen promotes the growth of estrogen receptor α-negative mammary tumours in mice undergoing mammary involution through stimulating pro-tumoral activities of neutrophils in the mammary tissue.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Lim, Chew Leng
Lin, Valerie Chun Ling
format Article
author Lim, Chew Leng
Lin, Valerie Chun Ling
author_sort Lim, Chew Leng
title Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice
title_short Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice
title_full Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice
title_fullStr Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice
title_full_unstemmed Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice
title_sort estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice
publishDate 2021
url https://hdl.handle.net/10356/152924
_version_ 1759855125673803776

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