Thrombin-derived host defence peptide modulates neutrophil rolling and migration in vitro and functional response in vivo

• Main Authors: Lim, Chun Hwee, Puthia, Manoj, Butrym, Marta, Tay, Hui Min, Lee, Michelle Zi Yi, Hou, Han Wei, Schmidtchen, Artur
• 其他作者: Interdisciplinary Graduate School (IGS)
• 格式: Article
• 語言: English
• 出版: 2017
• 主題: Neutrophils; Sepsis
• 在線閱讀: https://hdl.handle.net/10356/86509; http://hdl.handle.net/10220/44087
• 機構: Nanyang Technological University

Host defence peptides (HDPs) derived from the C-terminus of thrombin are proteolytically generated by enzymes released during inflammation and wounding. In this work, we studied the effects of the prototypic peptide GKY25 (GKYGFYTHVFRLKKWIQKVIDQFGE), on neutrophil functions. In vitro, GKY25 was show...