Human thrombin-derived host defense peptides inhibit neutrophil recruitment and tissue injury in severe acute pancreatitis

• المؤلفون الرئيسيون: Merza, Mohammed, Rahman, Milladur, Zhang, Songen, Hwaiz, Rundk, Regner, Sara, Schmidtchen, Artur, Thorlacius, Henrik
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: DRNTU::Science::Biological sciences::Human anatomy and physiology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/106667; http://hdl.handle.net/10220/25033; http://dx.doi.org/10.1152/ajpgi.00237.2014
• المؤسسة: Nanyang Technological University

Severe acute pancreatitis (AP) is characterized by leukocyte infiltration and tissue injury. Herein, we wanted to examine the potential effects of thrombin-derived host defense peptides (TDPs) in severe AP. Pancreatitis was provoked by infusion of taurocholate into the pancreatic duct or by intraper...