Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria

• Main Authors: Hansen, Finja C., Strömdahl, Ann-Charlotte, Mörgelin, Matthias, Schmidtchen, Artur, van der Plas, Mariena J. A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Host-defense peptides; Gram-negative bacteria
• Online Access: https://hdl.handle.net/10356/80519; http://hdl.handle.net/10220/43423
• Institution: Nanyang Technological University

Host-defense peptides play a fundamental role in the innate immune system by modulating inflammatory responses. Previously, it was shown that the thrombin derived host-defense peptide GKY25 inhibits LPS-induced responses of monocytes and macrophages in vitro, ex vivo, and in vivo. In this study, the...