Human thrombin-derived host defense peptides inhibit neutrophil recruitment and tissue injury in severe acute pancreatitis

• Main Authors: Merza, Mohammed, Rahman, Milladur, Zhang, Songen, Hwaiz, Rundk, Regner, Sara, Schmidtchen, Artur, Thorlacius, Henrik
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology
• Online Access: https://hdl.handle.net/10356/106667; http://hdl.handle.net/10220/25033; http://dx.doi.org/10.1152/ajpgi.00237.2014
• Institution: Nanyang Technological University

Severe acute pancreatitis (AP) is characterized by leukocyte infiltration and tissue injury. Herein, we wanted to examine the potential effects of thrombin-derived host defense peptides (TDPs) in severe AP. Pancreatitis was provoked by infusion of taurocholate into the pancreatic duct or by intraper...