Antimicrobial effects of helix D-derived peptides of human antithrombin III

• Main Authors: Papareddy, Praveen, Kalle, Martina, Bhongir, Ravi KV, Mӧrgelin, Matthias, Malmsten, Martin, Schmidtchen, Artur
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology
• Online Access: https://hdl.handle.net/10356/105880; http://hdl.handle.net/10220/20949
• Institution: Nanyang Technological University

Antithrombin III (ATIII) is a key antiproteinase involved in blood coagulation. Previous investigations have shown that ATIII is degraded by Staphylococcus aureus V8 protease, leading to release of heparin binding fragments derived from its D helix. As heparin binding and antimicrobial activity of p...