An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo

An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo

Host defense peptides are key components of the innate immune system, providing multi-facetted responses to invading pathogens. Here, we describe that the peptide GKS26 (GKSRIQRLNILNAKFAFNLYRVLKDQ), corresponding to the A domain of heparin cofactor II (HCII), ameliorates experimental septic shock. T...

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Bibliographic Details
Main Authors: Papareddy, Praveen, Kalle, Martina, Morgelin, Matthias, Schmidtchen, Artur, Malmsten, Martin, Singh, Shalini
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Medicine
Online Access:https://hdl.handle.net/10356/103671
http://hdl.handle.net/10220/19290
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/103671
http://hdl.handle.net/10220/19290

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