An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo

• المؤلفون الرئيسيون: Papareddy, Praveen, Kalle, Martina, Morgelin, Matthias, Schmidtchen, Artur, Malmsten, Martin, Singh, Shalini
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science::Medicine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/103671; http://hdl.handle.net/10220/19290
• المؤسسة: Nanyang Technological University

Host defense peptides are key components of the innate immune system, providing multi-facetted responses to invading pathogens. Here, we describe that the peptide GKS26 (GKSRIQRLNILNAKFAFNLYRVLKDQ), corresponding to the A domain of heparin cofactor II (HCII), ameliorates experimental septic shock. T...