Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides

Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides

Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear magnetic resonance spectroscopy (NMR), biophysical, mass spectrometry and cellular studies combined with in silico multiscale modelling, we...

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Bibliographic Details
Main Authors: Saravanan, Rathi, Holdbrook, Daniel A, Petrlova, Jitka, Singh, Shalini, Berglund, Nils A, Choong, Yeu Khai, Kjellström, Sven, Bond, Peter J, Malmsten, Martin, Schmidtchen, Artur
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2018
Subjects:
Thrombin-derived C-terminal Peptides
Endotoxin
DRNTU::Science::Medicine
Online Access:https://hdl.handle.net/10356/88214
http://hdl.handle.net/10220/45669
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/88214
http://hdl.handle.net/10220/45669

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