Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides

• Main Authors: Saravanan, Rathi, Holdbrook, Daniel A, Petrlova, Jitka, Singh, Shalini, Berglund, Nils A, Choong, Yeu Khai, Kjellström, Sven, Bond, Peter J, Malmsten, Martin, Schmidtchen, Artur
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Thrombin-derived C-terminal Peptides; Endotoxin; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/88214; http://hdl.handle.net/10220/45669
• Institution: Nanyang Technological University

Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear magnetic resonance spectroscopy (NMR), biophysical, mass spectrometry and cellular studies combined with in silico multiscale modelling, we...