Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

• Main Authors: van der Plas, Mariena J. A., Bhongir, Ravi K. V., Kjellström, Sven, Siller, Helena, Kasetty, Gopinath, Mörgelin, Matthias, Schmidtchen, Artur
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Biological sciences; Microbiology; Immunology
• Online Access: https://hdl.handle.net/10356/80660; http://hdl.handle.net/10220/40589
• Institution: Nanyang Technological University

Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which...