A peptide of heparin cofactor II inhibits endotoxin-mediated shock and invasive pseudomonas aeruginosa infection

• Main Authors: Kalle, Martina, Papareddy, Praveen, Kasetty, Gopinath, van der Plas, Mariena J. A., Mörgelin, Matthias, Malmsten, Martin, Schmidtchen, Artur
• Other Authors: Bozza, Patricia T.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104805; http://hdl.handle.net/10220/20286
• Institution: Nanyang Technological University

Sepsis and septic shock remain important medical problems with high mortality rates. Today's treatment is based mainly on using antibiotics to target the bacteria, without addressing the systemic inflammatory response, which is a major contributor to mortality in sepsis. Therefore, novel treatm...