Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which...

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Main Authors: van der Plas, Mariena J. A., Bhongir, Ravi K. V., Kjellström, Sven, Siller, Helena, Kasetty, Gopinath, Mörgelin, Matthias, Schmidtchen, Artur
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2016
Subjects:
Biological sciences
Microbiology
Immunology
Online Access:https://hdl.handle.net/10356/80660
http://hdl.handle.net/10220/40589
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-806602022-02-16T16:29:03Z Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses van der Plas, Mariena J. A. Bhongir, Ravi K. V. Kjellström, Sven Siller, Helena Kasetty, Gopinath Mörgelin, Matthias Schmidtchen, Artur Lee Kong Chian School of Medicine (LKCMedicine) Biological sciences Microbiology Immunology Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns in vitro and in vivo by preventing toll-like receptor dimerization and subsequent activation of down-stream signalling pathways. Thus, P. aeruginosa ‘hijacks’ an endogenous anti-inflammatory peptide-based mechanism, thereby enabling modulation and circumvention of host responses. Published version 2016-05-31T08:52:38Z 2019-12-06T13:54:11Z 2016-05-31T08:52:38Z 2019-12-06T13:54:11Z 2016 Journal Article van der Plas, M. J. A., Bhongir, R. K. V., Kjellström, S., Siller, H., Kasetty, G., Mörgelin, M., et al. (2016). Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses. Nature Communications, 7, 11567-. https://hdl.handle.net/10356/80660 http://hdl.handle.net/10220/40589 10.1038/ncomms11567 27181065 en Nature Communications © 2016 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ 13 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Biological sciences
Microbiology
Immunology
spellingShingle Biological sciences
Microbiology
Immunology
van der Plas, Mariena J. A.
Bhongir, Ravi K. V.
Kjellström, Sven
Siller, Helena
Kasetty, Gopinath
Mörgelin, Matthias
Schmidtchen, Artur
Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
description Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns in vitro and in vivo by preventing toll-like receptor dimerization and subsequent activation of down-stream signalling pathways. Thus, P. aeruginosa ‘hijacks’ an endogenous anti-inflammatory peptide-based mechanism, thereby enabling modulation and circumvention of host responses.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
van der Plas, Mariena J. A.
Bhongir, Ravi K. V.
Kjellström, Sven
Siller, Helena
Kasetty, Gopinath
Mörgelin, Matthias
Schmidtchen, Artur
format Article
author van der Plas, Mariena J. A.
Bhongir, Ravi K. V.
Kjellström, Sven
Siller, Helena
Kasetty, Gopinath
Mörgelin, Matthias
Schmidtchen, Artur
author_sort van der Plas, Mariena J. A.
title Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_short Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_full Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_fullStr Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_full_unstemmed Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_sort pseudomonas aeruginosa elastase cleaves a c-terminal peptide from human thrombin that inhibits host inflammatory responses
publishDate 2016
url https://hdl.handle.net/10356/80660
http://hdl.handle.net/10220/40589
_version_ 1725985715017220096

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