An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo

• Main Authors: Papareddy, Praveen, Kalle, Martina, Morgelin, Matthias, Schmidtchen, Artur, Malmsten, Martin, Singh, Shalini
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/103671; http://hdl.handle.net/10220/19290
• Institution: Nanyang Technological University

Host defense peptides are key components of the innate immune system, providing multi-facetted responses to invading pathogens. Here, we describe that the peptide GKS26 (GKSRIQRLNILNAKFAFNLYRVLKDQ), corresponding to the A domain of heparin cofactor II (HCII), ameliorates experimental septic shock. T...