Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies

• Main Authors: Kong, Jia Wen, Lam, Zhiyong, Chan, Kiat Hwa, Ganguly, Rakesh, Lee, Joey Jia-Ying, Loo, Lit-Hsin, Webster, Richard D., Wong, Zhen Xuan, Leong, Weng Kee
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Metals; Carbonyls; Cells; Cluster chemistry; Toxicity
• Online Access: https://hdl.handle.net/10356/153154
• Institution: Nanyang Technological University

A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.