Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides

• Main Authors: Lee J.J.Y., Leong W.K.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Osmium; Carbonyl Cluster
• Online Access: https://hdl.handle.net/10356/154584
• Institution: Nanyang Technological University

The reactions of the triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ (1) with a number of protected amino acids, tri- and pentapeptides were examined. The results show that reaction with the side chains follow the order: -SH > -COOH > -CONH₂, and there is a slight preference for the longer side c...