Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides
The reactions of the triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ (1) with a number of protected amino acids, tri- and pentapeptides were examined. The results show that reaction with the side chains follow the order: -SH > -COOH > -CONH₂, and there is a slight preference for the longer side c...
Saved in:
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2021
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/154584 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| id |
sg-ntu-dr.10356-154584 |
|---|---|
| record_format |
dspace |
| spelling |
sg-ntu-dr.10356-1545842021-12-28T08:52:38Z Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides Lee J.J.Y. Leong W.K. School of Physical and Mathematical Sciences Division of Chemistry and Biological Chemistry Science::Chemistry Osmium Carbonyl Cluster The reactions of the triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ (1) with a number of protected amino acids, tri- and pentapeptides were examined. The results show that reaction with the side chains follow the order: -SH > -COOH > -CONH₂, and there is a slight preference for the longer side chain of glutamic acid over aspartic acid. The trends observed are retained under physiological conditions and in the peptides. Ministry of Education (MOE) Nanyang Technological University This work was supported by Nanyang Technological University and the Ministry of Education (Research Grant No. RG121/18). 2021-12-28T08:52:38Z 2021-12-28T08:52:38Z 2020 Journal Article Lee J.J.Y. & Leong W.K. (2020). Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides. Journal of Organometallic Chemistry, 924, 121459-. https://dx.doi.org/10.1016/j.jorganchem.2020.121459 0022-328X https://hdl.handle.net/10356/154584 10.1016/j.jorganchem.2020.121459 2-s2.0-85089083422 924 121459 en RG121/18 Journal of Organometallic Chemistry © 2020 Elsevier B.V. All rights reserved. |
| institution |
Nanyang Technological University |
| building |
NTU Library |
| continent |
Asia |
| country |
Singapore Singapore |
| content_provider |
NTU Library |
| collection |
DR-NTU |
| language |
English |
| topic |
Science::Chemistry Osmium Carbonyl Cluster |
| spellingShingle |
Science::Chemistry Osmium Carbonyl Cluster Lee J.J.Y. Leong W.K. Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides |
| description |
The reactions of the triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ (1) with a number of protected amino acids, tri- and pentapeptides were examined. The results show that reaction with the side chains follow the order: -SH > -COOH > -CONH₂, and there is a slight preference for the longer side chain of glutamic acid over aspartic acid. The trends observed are retained under physiological conditions and in the peptides. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Lee J.J.Y. Leong W.K. |
| format |
Article |
| author |
Lee J.J.Y. Leong W.K. |
| author_sort |
Lee J.J.Y. |
| title |
Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides |
| title_short |
Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides |
| title_full |
Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides |
| title_fullStr |
Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides |
| title_full_unstemmed |
Towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster Os₃(CO)₁₀(NCCH₃)₂ : Its reactivity with amino acids and oligopeptides |
| title_sort |
towards understanding the mode of action of the cytotoxic triosmium carbonyl cluster os₃(co)₁₀(ncch₃)₂ : its reactivity with amino acids and oligopeptides |
| publishDate |
2021 |
| url |
https://hdl.handle.net/10356/154584 |
| _version_ |
1720447167819153408 |