TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae

• Main Authors: Mohammad Alfatah, Wong, Jin Huei, Krishnan, Vidhya Gomathi, Lee, Yong Cheow, Sin, Quan Feng, Goh, Corinna Jie Hui, Kong, Kiat Whye, Lee, Wei Ting, Lewis, Jacqueline, Hoon, Shawn, Arumugam, Prakash
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Transcriptional Response to Glucose; Target of Rapamycin Complex 1
• Online Access: https://hdl.handle.net/10356/153545
• Institution: Nanyang Technological University

Target of Rapamycin Complex 1 (TORC1) is a highly conserved eukaryotic protein complex that couples the presence of growth factors and nutrients in the environment with cellular proliferation. TORC1 is primarily implicated in linking amino acid levels with cellular growth in yeast and mammals. Although glucose deprivation has been shown to cause TORC1 inactivation in yeast, the precise role of TORC1 in glucose signaling and the underlying mechanisms remain unclear.