Elucidating the anticancer activities of guanidinium-functionalized amphiphilic random copolymers by varying the structure and composition in the hydrophobic monomer

• Main Authors: Tay, Joyce, Zhao, Yanli, Hedrick, James L., Yang, Yi Yan
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Anticancer Polymers; Guanidinium-Functionalized Polycarbonates,
• Online Access: https://hdl.handle.net/10356/153598
• Institution: Nanyang Technological University

Rationale: Use of traditional anticancer chemotherapeutics has been hindered by the multifactorial nature of multi-drug resistance (MDR) development and metastasis. Recently, cationic polycarbonates were reported as novel unconventional anticancer agents that mitigated MDR and inhibited metastasis....