A cell-based drug discovery assay identifies inhibition of cell stress responses as a new approach to treatment of epidermolysis bullosa simplex

• Main Authors: Tan, Tong San, Common, John E. A., Lim, John S. Y., Badowski, Cedric, Muhammad Jasrie Firdaus, Leonardi, Steven S., Lane, E. Birgitte
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Epidermolysis Bullosa Simplex
• Online Access: https://hdl.handle.net/10356/153607
• Institution: Nanyang Technological University

In the skin fragility disorder epidermolysis bullosa simplex (EBS), mutations in keratin 14 (K14, also known as KRT14) or keratin 5 (K5, also known as KRT5) lead to keratinocyte rupture and skin blistering. Severe forms of EBS are associated with cytoplasmic protein aggregates, with elevated kinase...