Induction of native c-di-GMP phosphodiesterases leads to dispersal of pseudomonas aeruginosa biofilms

• Main Authors: Andersen, Jens Bo, Kragh, Kasper Nørskov, Hultqvist, Louise Dahl, Rybtke, Morten, Nilsson, Martin, Jakobsen, Tim Holm, Givskov, Michael, Tolker-Nielsen, Tim
• Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Environmental engineering; Biofilm Dispersal; Phosphodiesterase
• Online Access: https://hdl.handle.net/10356/153679
• Institution: Nanyang Technological University

A decade of research has shown that the molecule c-di-GMP functions as a central second messenger in many bacteria. A high level of c-di-GMP is associated with biofilm formation, whereas a low level of c-di-GMP is associated with a planktonic single-cell bacterial lifestyle. c-di-GMP is formed by di...