Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

Itaconic acid is produced by immune responsive gene 1 (IRG1)-coded enzyme in activated macrophages and known to play an important role in metabolism and immunity. In this study, mechanism of itaconic acid functioning as an anti-inflammatory metabolite was investigated with molecular biology and immu...

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Bibliographic Details
Main Authors: Zhu, Xiaoyang, Guo, Yangyang, Liu, Zhigang, Yang, Jingyi, Tang, Huiru, Wang, Yulan
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2021
Subjects:
Online Access:https://hdl.handle.net/10356/153799
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Institution: Nanyang Technological University
Language: English